Sylvie Radix - Assistant Professor

Sylvie Radix

CV HAL

42 ans

Assistant professor in organic chemistry

Accreditation to supervise research (HDR diploma) in medicinal chemistry

Education and Experiences

 - since september 2004: Assistant professor in organic chemistry, Faculty of Pharmacy – University Claude Bernard Lyon 1. Part-time work (80%) since 2005.
- 2009: Accreditation to supervise research (HDR diploma) in medicinal chemistry
- 2003-2004: Lecturer in medicinal  chemistry, Faculty of Pharmacy – University Claude Bernard Lyon 1.
- Feb. 2002 - Feb. 2003: Research assistant - Pierre Fabre Laboratories / Prof. R. Barret (Faculty of Pharmacy – University Claude Bernard Lyon 1).
- Sept. 2000 - Sept. 2001: Research assistant - Prof. E. P. Kündig (Geneva University, CH).
- Oct. 1998 – March 2000: Research assistant - Prof. R. Grigg (Leeds University, UK).  
- 1998: Organic chemistry Ph-D at the University Claude Bernard Lyon 1.
- 1995: Chemistry engineering degree (E.S.C.I.L., Lyon) and Degree of Applied Studies in “fine chemistry” at the University Claude Bernard Lyon 1.
- 1991: Two-year technical degree in chemistry (I.U.T. of chemistry, University of Lyon 1).

Teaching area

Organic chemistry (health study first year and second-year classes in Pharmacy).
Responsible of an educational unit in Master 2 « Sciences du Médicament » of the Faculty of Pharmacy. Carbon-13 NMR teaching.

Research Interests

 Key words: drug design, synthesis, SAR
 - Infectiology: imidazo[4,5-b]pyridine derivatives (antibacterial agents,  bacterial tyrosine kinase inhibitors), cinnamide derivatives (bacterial efflux pump inhibitors)
 - Chemoresistances:  steroid-adenine hybrids, polycyclohexylidenes (Pgp).

Scientific expertise and reviewing

Reviewing for publications in Bioog. Med. Chem. Lett. and Monatsh. Chem.

Recent peer-reviewed journal articles

1. Zeinyeh, W.; Pilmé, J.; Radix, S.; Walchshofer, N. Regioselective N-Alkylation of Imidazo[4,5- b]pyridine-4-oxide Derivatives : An Experimental and DFT Study. Tetrahedron Lett. 2009, 50(16), 1828- 1833.
2. Zeinyeh, W.; Xia, H.; Lawton, P.; Radix, S.; Marminon, C.; Nebois, P.; Walchshofer, N. Synthesis and modulation properties of imidazo[4,5-b]pyridin-7-one and indazole-4,7-dione derivatives towards the Cryptosporidium parvum CpABC3 transporter. Eur. J. Med. Chem. 2010, 45, 2567-2577.
3. Zeinyeh, W.; Alameh, G.; Radix, S.*; Grenot, C.; Dumontet, C.; Walchshofer, N.* Design, synthesis and evaluation of progesterone-adenine hybrids as bivalent inhibitors of P-glycoprotein-mediated multidrug efflux. Bioorg. Med. Chem. Lett. 2010, 20, 3165-3168.
4. Zeinyeh, W.; Mahiout, Z.; Radix, S.*; Lomberget, T.; Dumoulin, A.; Barret, R.; Grenot, C.; Rocheblave, L.; Matera, E.-L.; Dumontet, C.; Walchshofer, N.* Progesterone–adenine hybrids as bivalent inhibitors of P-glycoprotein-mediated multidrug efflux: Design, synthesis, characterization and biological evaluation. Steroids 2012, 77, 1177-1191.

 Recent posters

46th International Conference on Medicinal Chemistry, Reims, 30/06/2010-02/07/2010
W. Zeinyeh, G. Alameh, S. Radix, L. Rocheblave, C. Grenot, C. Dumontet, N. Walchshofer. Design and synthesis of progesterone-adenine hybrids as bivalent inhibitors of ABC-transporter-mediated multidrug resistance.

19th Meeting of the Group of Medicinal Chemists of the Atlantic Arc (GP2A), Rouen, 01/09-02/09/2010
W. Zeinyeh, G. Alameh, S. Radix, L. Rocheblave, C. Grenot, C. Dumontet, N. Walchshofer. Design and synthesis of new bivalent inhibitors of ABC-transporter-mediated multidrug resistance.

47th International Conference on Medicinal Chemistry, Lyon, 06/07-08/07/2011
K. Romane, L. Rocheblave, S. Radix, N. Walchshofer. Cinnamide derivatives as efflux pump inhibitors to overcome bacterial multi-drug resistance.

7th Edition of the « Rencontre de Chimie Organique » (RCO, Marseille, 14/06-15/06/2012
K. Romane, L. Rocheblave, S. Radix, N. Walchshofer. Synthèse de derives cinnamides comme inhibiteurs de pompes d’efflux (IPE) chez les bactéries.