Luc Rocheblave - Assistant Professor

Photo Luc Rocheblave

Birth Date: 28th October 1971 in Montpellier (Hérault)

Current position:  Associate Professor in Organic Chemistry

Education

- 1997: M2 in Organic Chemistry :"Biomolecules : Synthesis, Structure, Reactivity". University of Montpellier, France.
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1997-2000 : PhD in Organic Chemistry. Thesis : "Conception, synthesis and antiviral evaluation of new HIV inhibitors". University Aix-Marseille II, France (Pr Jean-Louis KRAUS).
- 2012: Accreditation to supervise research (HDR diploma) in Organic Chemistry. University of Lyon (UCB Lyon 1).

Work Experience

- 2001- 2002: Post-Doc research work (Marie-Curie grant). Project : " Design and Synthesis of Novel Paclitaxel (Taxol) Mimics Using a Common Pharmacophore Model for Microtubule-Stabilising Anticancer Agents (MSAAs). School of Pharmacy. Siena, Italy (Pr Maurizio BOTTA).- 2003-2005: Post-Doc research work (ARC grant).Laboratory of amino-acids peptides and proteins. Project : " Towards total synthesis of Apratoxin A. Synthesis and evaluation of new RGD labeled peptides, for specific tumor cell targeting". University of Montpellier, France (Pr Jean MARTINEZ).
- 2005-2006: ATER University Aix-Marseille III, France (Pr Christian ROUSSEL).
- 2006-2007: ATER University Aix-Marseille III, France (Pr Michel CHANON).

Scientific Production

15 publications and 11 proceedings.

Research Domain

In our group we work in the field of medicinal chemistry. Steroids and heterosteroids could be very efficient compounds to overcome Multi-Drug Resistance (MDR) in P-glycoprotein (Pgp). We also develop cinnamides derivatives as efflux pump inhibitors targeting resistant bacterial.


Publications

26) Zeinyeh, W.; Mahiout, Z.; Radix, S.; Lomberget, T.; Dumoulin, A.; Barret, R.; Grenot, C.; Rocheblave, L.; Matera, E-L.; Dumontet, C.; Walchshofer, N. " Progesterone–adenine hybrids as bivalent inhibitors of P-glycoprotein-mediated multidrug efflux: Design, synthesis, characterization and biological evaluation " Steroids, 2012, 1177-1191. IF 2,905
25) Ibrahim-Ouali, M.; Hamze, K.; Rocheblave L. "Synthesis of 12-oxa, 12-aza and 12-thia cholanetriols" Steroids, 2011, 324-330. IF 2,905
24) Schmidt, J.; Garambois, V.; Rocheblave, L.; Martinez, J.; Pelegrin, A.; Cavelier, F.; Vives, E. "Tetracyclopeptide inhibitor of metastatic proliferation" Bulletin du Cancer 2010 Volume: 97 Issue: S4 Pages: S62.
23) Ibrahim-Ouali, M.; Rocheblave L. "Synthesis of Heterosteroids. First Synthesis of Thia Steroids from Cholic Acid" Steroids, 2010, 701-709. IF 2,905
22) Schmidt, J.; Garambois, V.; Rocheblave, L.; Martinez, J.; Pelegrin, A.; Cavelier, F.; Vives, E. "Cyclization of Peptides through a Urea Bond: Application to the Arg-Gly-Asp Tripeptide" ChemBioChem, 2010, 1083-1092. IF 3,824
21) Ibrahim-Ouali, M., Botsi-Nkomendi, N.; Rocheblave L. "Synthesis of Heterosteroids. First Synthesis of Oxa Steroid from Cholic Acid" Tetrahedron Letters, 2010, 93-95. IF 2,660
20) Schmidt, J.; Rocheblave, L.; Martinez, J.; Pelegrin, A.; Cavelier, F.; Vives, E. "Synthesis of new tetracyclic RGD peptides for specific tumor cell targeting" Bulletin du Cancer 2008 Volume: 95 Issue: SI Pages: S40.
19) Schmidt, J.; Rocheblave, L.; Martinez, J.; Pelegrin, A.; Cavelier, F.; Vives, E. "Synthesis of new tetracyclic RGD peptides for specific tumor cell targeting" Journal of Peptide Science 2008 Volume: 14 Issue: 8 Pages: 140.
18) Schmidt, J.; Rocheblave, L.; Martinez, J.; Pelegrin, A.; Cavelier, F.; Vives, E. "Specific tumor cell targeting using a new class of RGD tetracyclopeptide" 2007 Biopolymers: Pages: 595.
17) Ibrahim-Ouali, M.; Rocheblave, L. "Recent advances in azasteroids chemistry". Steroids, 2008, 375-407.
16) Renzulli, M.L.; Rocheblave, L.; Avramova, S.; Galletti, E.; Castagnolo, D.; Tafi, A.; Corelli, F. and Botta, M. "Studies towards the synthesis of the bicyclic 3,8-secotaxane diterpenoid system using a ring closing metathesis strategy" Tetrahedron, 2007, 497-509.
15) Schmidt, J.; Rocheblave, L.; Martinez, J.; Pèlegrin, A.; Cavelier, F. and Vivès, E. "Synthesis of new cyclic RGD peptides for specific tumor cell targeting" Peptides, 2006, 237.
14) Renzulli, M.L.; Rocheblave, L.; Avramova, S.; Galletti, E.; Castagnolo, D.; Maccari, L.; Forli, S.; Manetti, F.; Corelli, F. and Botta, M. "A pharmacophore modeling approach to design new taxol® mimics: towards the synthesis of potential anticancer and MDR-reversing agent (ML-1836GR)" Arkivoc, 2006, viii, 111-130.
13) Rocheblave, L.; Gilles, A.; Martinez, J.; Cavelier, F. and Vivès E. "Synthesis of fluorescein labeled peptides". Peptides, 2004, 565-566.
12) Gilles, A.; Rocheblave, L.; Martinez, J.; Stien, D.; Vivès E. and Cavelier, F. "Towards total synthesis of Apratoxin A". Peptides, 2004, 319-320.
11) Renzulli, M.L.; Rocheblave, L.; Avramova, S.; Corelli, F.; Botta, M. "Studies toward Taxuspine X, a potent multidrug-resistance reversing agent, via ring closing metathesis strategy" Tetrahedron Letters, 2004, 45, 5155-5158.
10) Rocheblave, L.; Bihel, F.; De Michelis, C.; Priem, G.; Courcambeck, J.; Bonnet, B.; Chermann, J. C.; Kraus, J. L. " Synthesis and Antiviral Activity of New Anti-HIV Amprenavir Bioisosteres " J. Med. Chem. 2002, 15, 3321-3324.
9) Rocheblave, L.; Priem, G.; Courcambeck, J.; De Michelis, C.; Bonnet, B.; Chermann, J. C.; Kraus, J. L. "Synthesis of new HIV protease inhibitors containing a novel (2-Phenylsulfanyl-1-hydroxyethyl)amide isostere". Peptides, 2000, 723-724.
8) Priem, G.; Courcambeck, J.; Rocheblave, L.; De Michelis, C.; Aubertin, A. M.; Chermann, J. C.; Kraus, J. L. "The use of modified phenylalanine bioisosteres for the design of HIV inhibitors". Peptides, 2000, 719-720.
7) De Michelis, C.; Rocheblave, L.; Priem, G.; Chermann, J.C. and J.L. Kraus . "New Anti-HIV Derivatives: Synthesis and Antiviral Evaluation." Bioorg. Med. Chem. 2000, 8, 1253-1262.
6) Priem, G.; Rocheblave, L.; De Michelis, C.; Courcambeck, J.; Kraus, J. L. "Synthesis and chemical reactivity of thiophenoxyphenylalanine bioisosteres, suitable synthons for the design of HIV protease inhibitors.» J. Chem. Soc., Perkin Trans. 1 2000, 5, 819-824.
5) Medou, M.; Priem, G.; Rocheblave, L.; Pepe, G.; Meyer, M.; Chermann, J.C.; Kraus, J.L. "Synthesis and anti-HIV activity of a-thiophenoxy-hydroxyethylaminde derivative." Eur. J. Med. Chem., 1999, 34, 625-638.
4) Rocheblave, L.; Priem, G.; De Michelis, C. and Kraus, J.L. "Potent HIV protease inhibitors containing a novel (2-phenylsulfanyl-1-hydroxyethyl)amide isostere." Tetrahedron Letters, 1999, 40, 4173-4176.
3) Medou, M.; Bouygues, M.; Rocheblave, L.; Chermann, J.C.; Kraus, J.L. "Synthesis and Anti-HIV Activities of Symmetrical N1,N3-dibenzyl-2-hydroxy-propane Derivatives." Bioorganic and Medicinal Chemistry Letters 1998, 8, 1861-1866.
2) Paris, M.; Pothion, C.; Heitz, A.; Rocheblave, L.; Rouch, F.; Fehrentz, J-A.; Martinez, J. "Solid phase synthesis of peptide aldehydes". Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries: Peptides, 1997, 15-18.
1) Pothion, C.; Paris, M.; Heitz, A.; Rocheblave, L.; Rouch, F.; Fehrentz, J.A. and Martinez J. "Use of ozonolysis in the synthesis of C-terminal peptide aldehydes on solid support." Tetrahedron Letters 1997, 38, 7749-7752.