Laurent Ettouati - Assistant Professor

56 ans, married, 4 children, French.

Current position

Assistant Professor in Medicinal Chemistry since october 1992, Faculty of Pharmacy, University of Lyon 1, France.


Accreditation to supervise research (Habilitation à Diriger des Recherches), October 2000, University of Lyon 1, France.

Ph. D. in Chemistry, University of Paris XI, March 1991, Orsay, France.

Research Interests

Extraction and structural determination of biologically active products from plant and marine organisms.
Semi-synthesis of biologically active products.
Synthesis of peptides and pseudopeptides on solid phase and in solution.
Design and synthesis of pseudopeptide analogs.
Synthesis of bioactive indenoindoles.
Study of API stability.


Post-doctoral training, 1991-1992, Prs. Blunt and Munro’s Laboratory, University of Canterbury, Christchurch, New Zealand.

Publications since 2010

F. Alchab, E. Sibille, L. Ettouati, E. Bana, Z. Bouaziz, A. Mularoni, E. Monniot, D. Bagrel, J. Jose, M. Le Borgne, P. Chaimbault. Screening of indeno[1,2-b]indoloquinones by MALDI-MS: a new set of potential CDC25 phosphatase inhibitors brought to light. J Enzyme Inhib Med Chem. 2016 Jun 30:1-8.

F. Alchab, L. Ettouati, Z. Bouaziz, A. Bollacke, J.-G.Delcros , C. G.W. Gertzen, H. Gohlke, N. Pinaud, M. Marchivie, J. Guillon, B. Fenet, J. Jose, M. Le Borgne. Synthesis, Biological Evaluation and Molecular Modeling of Substituted Indeno[1,2-b]indoles as Inhibitors of Human Protein Kinase CK2. Pharmaceuticals 2015, 8(2), 279-302.

Z. Bourezg, N. Cartiser, L. Ettouati, J. Guillon, A. Lacoudre, N. Pinaud, M. Le Borgne, H. Fessi. Structural elucidation of two photolytic degradation products of tetrabenazine. J. Pharm. Biomed. Anal., 2014, 91C, 138-43.

F. Al Chab, B. Fenet, M. Le Borgne, J. Jose, Noël Pinaud, Jean Guillon et L. Ettouati.1H and 13C NMR assignments of bioactive indeno[1,2-b]indole-10-one derivatives. Magn. Res. Chem., 2013, 51, 837–841.

A. Arnaud, A. Koubeissi, L. Ettouati, J. Paris, A. di Pietro et P. Falson. P-Glycoprotein-Specific Non-Competitive Peptide and Peptidomimetic Modulators. French Patent FR 2950888A1, published April 8 2011. World Patent WO 2011/042654A1 published April 14th 2011.

O. Arnaud, A. Koubeissi, L. Ettouati, R. Terreux, G. Alamé, C. Grenot, C. Dumontet, A. Di Pietro, J. Paris and P. Falson. Potent and fully non-competitive inhibitor of multidrug resistance P-glycoprotein. J. Med. Chem., 2010, 53, 6720-6729.


Award in Plant Biology from l'Académie Nationale de Pharmacie, 1990.