Zouhair Bouaziz - Assistant Professor

Update March 2017

1993-2017: Associate Professor in Organic Chemistry, University Lyon1.

2002: Accreditation to supervise research (HDR diploma), University Lyon1.

Professional address: Faculty of Pharmacy, University Lyon1, EA 4446 « Bioactive Molecules and Medicinal Chemistry (B2MC) ». 8, avenue Rockefeller F-69373 Lyon Cedex 08 France.

Ph: +33 (0)4 78 77 72 53

Mail: bouaziz@univ-lyon1.fr

Website: http://b2mc.univ-lyon1.fr

ResearchGate page - https://www.researchgate.net/profile/Zouhair_Bouaziz

 TEACHING ACTIVITY

My Organic Chemistry teaching load amounts to 192 hours/year for students of:

- First Common Year for Health Studies (PACES).

- Second year of pharmacy (I am responsible for this teaching unit)

- Master « Sciences du Médicament ».

- Optional teaching: « Synthesis, reactivity and characterization of aromatic compounds ».

PRESENT RESEARCH ACTIVITY

Design, synthesis and structural optimization of bioactive molecules: Indeno[1,2-b]indole derivatives as inhibitors of the Protein Kinase CK2 and the Breast Cancer Resistance Protein BCRP (or ABCG2).

 PUBLICATIONS SINCE 2015

1) Gustavo Jabor Gozzi, Zouhair Bouaziz, Evelyn Winter, Nathalia Daflon-Yunes, Dagmar Aichele, Abdelhamid Nacereddine, Christelle Marminon, Glaucio Valdameri, Wael Zeinyeh,Andre Bollacke, Jean Guillon, Aline Lacoudre, Noel Pinaud, Silvia M. Cadena, Joachim Jose, Marc Le Borgne, and Attilio Di Pietro. Converting Potent Indeno[1,2-b]indole Inhibitors of Protein Kinase CK2 into Selective Inhibitors of the Breast Cancer Resistance Protein ABCG2. J. Med. Chem. 2015, 58, 265-277. (IF 5,589)

2) Gustavo Jabor Gozzi, Zouhair Bouaziz, Evelyn Winter, Nathalia Daflon-Yunes, Mylène Honorat, Nathalie Guragossian, Christelle Marminon, Glaucio Valdameri, Andre Bollacke, Jean Guillon, Noël Pinaud, Mathieu Marchivie, Silvia M Cadena, Joachim Jose, Marc Le Borgne, Attilio Di Pietro. Phenolic indeno[1,2-b]indoles as ABCG2-selective potent and nontoxic inhibitors stimulating basal ATPase activity. Drug Design, Development and Therapy 2015, 9, 3481-3495. (IF 2,881)

3) Zouhair Bouaziz, Samar Issa, Jacques Gentili, Andreas Gratz, Andre Bollacke, Matthias Kassack, Joachim Jose, Lars Herfindal, Gro Gausdal, Stein Ove Døskeland, Catherine Mullie, Pascal Sonnet, Camille Desgrouas, Nicolas Taudon, Glaucio Valdameri, Attilio Di Pietro, Milad Baitiche and Marc Le Borgne. Biologically active carbazole derivatives: focus on oxazinocarbazoles and related compounds. J. Enzyme Inhib. Med. Chem. 2015, 30(2), 180–188. (IF 3,428)

4) Faten Alchab, Laurent Ettouati, Zouhair Bouaziz, Andre Bollacke, Jean-Guy Delcros, Christoph G.W. Gertzen, Holger Gohlke, Noël Pinaud, Mathieu Marchivie, Jean Guillon, Bernard Fenet, Joachim Jose and Marc Le Borgne. Synthesis, Biological Evaluation and Molecular Modeling of Substituted Indeno[1,2-b]indoles as Inhibitors of Human Protein Kinase CK2. Pharmaceuticals 2015, 8, 279-302.

 5) Christelle Marminon, Abdelhamid Nacereddine, Zouhair Bouaziz, Pascal Nebois, Joachim Jose, Marc Le Borgne. Microwave-assisted oxidation of indan-1-ones into ninhydrins. Tetrahedron Lett. 2015, 56, 1840–1842. (IF 2,347)

6) Billel Belhani, Malika Berredjem, Marc Le Borgne, Zouhair Bouaziz, Jacques Lebreton and Nour-Eddine Aouf. A one-pot three-component synthesis of novel a-sulfamidophosphonates under ultrasound irradiation and catalyst-free conditions. RSC Adv. 2015, 5, 39324–39329. (IF 3,289)

7) Abdelmalek Bouraiou, Sofiane Bouacida, Hocine Merazig, Aissa Chibani and Zouhair Bouaziz. Crystal structure of 13-(2-methoxyphenyl)-3,4-dihydro-2H-indazolo[1,2-b]phthalazine-1,6,11(13H)-trione. Acta Cryst. 2015, E71, o604–o605. (IF 2,333)

8) Esma Lamera, Saida Benzerka, Abdelmalek Bouraiou, Sofiane Bouacida, Hocine Merazig, Aissa Chibani, Marc Le Borgne and Zouhair Bouaziz. Crystal structure of 13-phenyl-2,3,4,13-tetrahydro-1H-indazolo[1,2-b]phthalazine-1,6,11-trione. Acta Cryst. 2015. E71, o1036–o1037. (IF 2,333)

 9) Nathalie Guragossian, Gustavo Jabor Gozzi, Bruno Fouillet, Marie-Paule Gustin, Raphaël Terreux, Zouhair Bouaziz, Christelle Marminon, Joachim Jose, Attilio Di Pietro, Markku Pasanen and Marc Le Borgne. Chemical Informatics 2016, Vol. 2, No 2:6, 1-9.

10) Roumaissa Belguedj, Esma Lamera, Abdelmalek Bouraiou, Zouhair Bouaziz and Aissa Chibani. Methyl-3-(quinolin-2-yl)indolizine-1-carboxylate. Molbank 2016, M883.

11) Faten Alchab, Estelle Sibille, Laurent Ettouati, Emilie Bana, Zouhair Bouaziz, Angélique Mularoni, Elodie Monniot, Denyse Bagrel, Joachim Jose, Marc Le Borgne, and Patrick Chaimbault, Screening of indeno[1,2-b]indoloquinones by MALDI-MS: a new set of potential CDC25 phosphatase inhibitors brought to light. J Enzyme Inhib Med Chem 2016, 31(S3): 25–32. (IF 3,428)

12) Samer Haidar, Zouhair Bouaziz, Christelle Marminon, Tuomo Laitinen, Antti Poso, Marc Le Borgne and Joachim Jose. Development of Pharmacophore Model for Indeno[1,2-b]indoles as Human Protein Kinase CK2 Inhibitors and Database Mining. Pharmaceuticals 2017, 10, 8, 1-13.

13) Esma Lamera, Sofiane Bouacida, Marc Le Borgne, Zouhair Bouaziz, Abdelmalek Bouraiou. Sequential MCR/Fisher indolization strategy for the construction of polycyclic carbazole derivatives. Tetrahedron Letters 2017, 58, 1305–1307. (IF 2,347)

14) Esma Lamera, Sofiane Bouacida, Hocine Merazig, Aissa Chibani, Marc Le Borgne, Zouhair Bouaziz and Abdelmalek Bouraiou. DMAP as new efficient catalysts for one-pot synthesis of condensed phthalazine. Accepted in Zeitschrift fuer Naturforschung B – Chemical Sciences, February 2017. (IF 0.686)